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KMID : 0350519920450010229
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Journal of Catholic Medical College
1992 Volume.45 No. 1 p.229 ~ p.237
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The Basal Hormonal Pattern of 'Atypical' Polycystic Ovarian Disease
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Abstract
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To evaluate pattern of basal hormones, 32 case showing clinical symptoms of polycystic ovarian disease(PCOD) including oligoanovulation, androgen excess and obesity without typical ovarian change of PCOD by bimanual pelvic examination and pelvic
sonography were selected among the patients registered at the Infertility Clinic of Department of Obstetrics and Gynecology, Catholic University Medical College, and arbitrarily classified as an 'atypical' PCOD group(group P).
For comparison, 20 normal women with regular mestruations and normal pelvic sonographic findings of both ovaries were considered as normal control(group N).
Basal hormonal levels of serum LH, FSH, LH/FSH ratio, prolactin(hPRL), estradiol(E2), testos terone(T) and dehydroepiandrosteronesulfate(DHEA-S) were measured using the radioimmunoassay. The mean hormonal values of the group P were statistically
compared with those of group N
@ES The results were as follows:
@EN 1. The mean value of serum LH in the group P, 26.52*9.35mIU/ml, was significantly higher than in the group N, 9.94*2.22mIU/ml(p=0.0001).
2. The mean value of LH/FSH ratio in the group P, 4.16*0.69, was significantly higher than in the group N, 1.70*0.40(p=0.0001).
3. The mean value of serum E2 in the group P, 80.89*23.00pg/ml, was significantly lower than in group N, 100.23*17.66pg/ml(p=0.0021).
4. The mean value of serum T in the group P, 1.03*0.42ng/ml, was significantly higher than in the group N, 0.44*0.20 ng/ml(p=0.0001).
5. The mean values of serum FSH, hPRL and DHEA-S revealed no statitical diferences between the group P and N(p=0.79, p=0.07 and p=0.570.
The results showed that the patterns of the basal hormonse in the group P were quite different from group N and furghermore very similar to the well known pattern in the typical PCOD.
This results may contribute in diagnosis and management of 'atypical' PCOD with same clinical symptoms without typical ovarian morphologic findings of the typical PCOD.
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KEYWORD
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